Breaking the VE-cadherin bonds

Details Breaking the VE-cadherin bonds Breaking the VE-cadherin bonds

2008-12-26

arxiv.org/abs/0812.4707v1

FEBS Letters / FEBS-Letters; FEBS Microbiol Lett (2008) epub ahead of print

Biology

Quantitative Biology

Cell Behavior

Scientific paper

10.1016/j.febslet.2008.11.032

Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture. Conversely, anti-PIFs protect from VE-cadherin disruption and enhance cell cohesion. These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis.

Affiliated with

Also associated with

No associations

Rating

Breaking the VE-cadherin bonds does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Breaking the VE-cadherin bonds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Breaking the VE-cadherin bonds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-191451