Biology – Quantitative Biology – Populations and Evolution
Scientific paper
2008-03-06
Biology
Quantitative Biology
Populations and Evolution
v1 to v2: Minor changes - corrected some typos, clarified some sentences, and added a small number of additional comments. No
Scientific paper
We consider an infectious disease spreading along the edges of a network which may have significant clustering. The individuals in the population have heterogeneous infectiousness and/or susceptibility. We define the out-transmissibility of a node to be the marginal probability that it would infect a randomly chosen neighbor given its infectiousness and the distribution of susceptibility. For a given distribution of out-transmissibility, we find the conditions which give the upper [or lower] bounds on size and probability of an epidemic, under weak assumptions on the transmission properties, but very general assumptions on the network. We find similar bounds for a given distribution of in-transmissibility (the marginal probability of being infected by a neighbor). We also find conditions giving global upper bounds on size and probability. The distributions leading to these bounds are network-independent. In the special case of networks with high girth (locally tree-like), we are able to prove stronger results. In general the probability and size of epidemics are maximal when the population is homogeneous and minimal when the variance of in- or out-transmissibility is maximal.
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