Biochemical analysis of human breast tissues using FT-Raman spectroscopy

Details Biochemical analysis of human breast tissues using FT-Raman spectroscopy Biochemical analysis of human breast tissues using FT-Raman spectroscopy

2006-03-31

arxiv.org/abs/q-bio/0603037v1

Biology

Quantitative Biology

Tissues and Organs

29 pages, 9 figures. accepted Journal of Biomedical Optics

Scientific paper

10.1117/1.2363362

In this work we employ the Fourier Transform Raman Spectroscopy to study normal and tumoral human breast tissues, including several subtypes of cancers. We analyzed 194 Raman spectra from breast tissues that were separated into 9 groups according to their corresponding histopathological diagnosis. The assignment of the relevant Raman bands enabled us to connect the several kinds of breast tissues (normal and pathological) to their corresponding biochemical moieties alterations and distinguish among 7 groups: normal breast, fibrocystic condition, duct carcinoma-in-situ, duct carcinoma-in-situ with necrosis, infiltrating duct carcinoma not otherwise specified, colloid infiltrating duct carcinoma and invasive lobular carcinomas. We were able to establish the biochemical basis for each spectrum, relating the observed peaks to specific biomolecules that play special role in the carcinogenesis process. This work is very useful for the premature optical diagnosis of a broad range of breast pathologies. We noticed that we were not able to differentiate inflammatory and medullary duct carcinomas from infiltrating duct carcinoma not otherwise specified.

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