Binding properties and evolution of homodimers in protein-protein interaction networks

Details Binding properties and evolution of homodimers in protein-protein interaction networks Binding properties and evolution of homodimers in protein-protein interaction networks

2005-01-04

arxiv.org/abs/q-bio/0501004v1

Nucleic Acids Research 2005 33(11):3629-3635

Biology

Quantitative Biology

Genomics

16 pages, 3 figures

Scientific paper

We demonstrate that Protein-Protein Interaction (PPI) networks in several eucaryotic organisms contain significantly more self-interacting proteins than expected if such homodimers randomly appeared in the course of the evolution. We also show that on average homodimers have twice as many interaction partners than non-self-interacting proteins. More specifically the likelihood of a protein to physically interact with itself was found to be proportional to the total number of its binding partners. These properties of dimers are are in agreement with a phenomenological model in which individual proteins differ from each other by the degree of their ``stickiness'' or general propensity towards interaction with other proteins including oneself. A duplication of self-interacting proteins creates a pair of paralogous proteins interacting with each other. We show that such pairs occur more frequently than could be explained by pure chance alone. Similar to homodimers, proteins involved in heterodimers with their paralogs on average have twice as many interacting partners than the rest of the network. The likelihood of a pair of paralogous proteins to interact with each other was also shown to decrease with their sequence similarity. This all points to the conclusion that most of interactions between paralogs are inherited from ancestral homodimeric proteins, rather than established de novo after the duplication. We finally discuss possible implications of our empirical observations from functional and evolutionary standpoints.

Affiliated with

Also associated with

No associations

Rating

Binding properties and evolution of homodimers in protein-protein interaction networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Binding properties and evolution of homodimers in protein-protein interaction networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Binding properties and evolution of homodimers in protein-protein interaction networks will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-529590