Computer Science – Computer Vision and Pattern Recognition
Scientific paper
2010-12-31
Computer Science
Computer Vision and Pattern Recognition
Scientific paper
Accumulating evidence has shown that iron is involved in the mechanism underlying many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Abnormal (higher) iron accumulation has been detected in the brains of most neurodegenerative patients, especially in the basal ganglia region. Presence of iron leads to changes in MR signal in both magnitude and phase. Accordingly, tissues with high iron concentration appear hypo-intense (darker than usual) in MR contrasts. In this report, we proposed an improved binary hypointensity description and a novel nonbinary hypointensity description based on principle components analysis. Moreover, Kendall's rank correlation coefficient was used to compare the complementary and redundant information provided by the two methods in order to better understand the individual descriptions of iron accumulation in the brain.
Chen Xiaojing
Lew Michael S.
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