Mathematics – Dynamical Systems
Scientific paper
2008-09-10
SIAM Journal on Applied Dynamical Systems 8, 4 (2009) 1591?1631
Mathematics
Dynamical Systems
Scientific paper
10.1137/080732237
We investigate a model of the GnRH pulse and surge generator, with the definite aim of constraining the model GnRH output with respect to a physiologically relevant list of specifications. The alternating pulse and surge pattern of secretion results from the interaction between a GnRH secreting system and a regulating system exhibiting fast-slow dynamics. The mechanisms underlying the behavior of the model are reminded from the study of the Boundary-Layer System according to the "dissection method" principle. Using singular perturbation theory, we describe the sequence of bifurcations undergone by the regulating (FitzHugh-Nagumo) system, encompassing the rarely investigated case of homoclinic connexion. Basing on pure dynamical considerations, we restrict the space of parameter search for the regulating system and describe a foliation of this restricted space, whose leaves define constant duration ratios between the surge and the pulsatility phase in the whole system. We propose an algorithm to fix the parameter values to also meet the other prescribed ratios dealing with amplitude and frequency features of the secretion signal. We finally apply these results to illustrate the dynamics of GnRH secretion in the ovine species and the rhesus monkey.
Clement Frederique
Vidal Alexandre
No associations
LandOfFree
Bifurcation-based parameter tuning in a model of the GnRH pulse and surge generator does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Bifurcation-based parameter tuning in a model of the GnRH pulse and surge generator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bifurcation-based parameter tuning in a model of the GnRH pulse and surge generator will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-161035