Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling

Biology – Quantitative Biology – Genomics

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Scientific paper

10.1093/biostatistics/kxl028

This paper describes a Bayesian statistical method for determining the genetic basis of a complex genetic trait. The method uses a sample of unrelated individuals classified into two groups, for example cases and controls. Each group is assumed to have been genotyped at a battery of marker loci using a laboratory effort efficient technique called DNA pooling. The aim is to detect and map a quantitative trait locus (QTL) that is not one of the typed markers. The method works by conducting an exact Bayesian analysis under a number of simplifying population genetic assumptions that are somewhat unrealistic. Despite this, the method is shown to perform acceptably on datasets simulated under a more realistic model, and furthermore is shown to outperform classical single point methods.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-295387

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.