Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2011-11-13
Epilepsy & Behavior 22, S7-S17 (2011)
Biology
Quantitative Biology
Neurons and Cognition
27 pages with 8 figures and 2 tables
Scientific paper
10.1016/j.yebeh.2011.09.011
One of epileptology's fundamental aims is the formulation of a universal, internally consistent seizure definition. To assess this aim's feasibility, three signal analysis methods were applied to a seizure time series and performance comparisons were undertaken among them and with respect to a validated algorithm. One of the methods uses a Fisher's matrix weighted measure of the rate of parameters change of a 2n order auto-regressive model, another is based on the Wavelet Transform Maximum Modulus for quantification of changes in the logarithm of the standard deviation of ECoG power and yet another employs the ratio of short-to-long term averages computed from cortical signals. The central finding, fluctuating concordance among all methods' output as a function of seizure duration, uncovers unexpected hurdles in the path to a universal definition, while furnishing relevant knowledge in the dynamical (spectral non-stationarity and varying ictal signal complexity) and clinical (probable attainability of consensus) domains.
Lyubushin Alexey
Osorio Ivan
Sornette Didier
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