Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2009-07-23
Biology
Quantitative Biology
Subcellular Processes
18 pages, 3 figures
Scientific paper
Due to the stochastic nature of biochemical processes, the copy number of any given type of molecule inside a living cell often exhibits large temporal fluctuations. Here, we develop analytic methods to investigate how the noise arising from a bursting input is reshaped by a transport reaction which is either linear or of the Michaelis-Menten type. A slow transport rate smoothes out fluctuations at the output end and minimizes the impact of bursting on the downstream cellular activities. In the context of gene expression in eukaryotic cells, our results indicate that transcriptional bursting can be substantially attenuated by the transport of mRNA from nucleus to cytoplasm. Saturation of the transport mediators or nuclear pores contributes further to the noise reduction. We suggest that the mRNA transport should be taken into account in the interpretation of relevant experimental data on transcriptional bursting.
Ma Yu-qiang
Tang Lei-Han
Xiong Li-ping
No associations
LandOfFree
Attenuation of transcriptional bursting in mRNA transport does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Attenuation of transcriptional bursting in mRNA transport, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Attenuation of transcriptional bursting in mRNA transport will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-355377