Analysis of a Mathematical Model of Ischemic Cutaneous wounds

Details Analysis of a Mathematical Model of Ischemic Cutaneous wounds Analysis of a Mathematical Model of Ischemic Cutaneous wounds

2009-09-30

arxiv.org/abs/0910.0039v2

Mathematics

Analysis of PDEs

Scientific paper

Chronic wounds represent a major public health problem affecting 6.5 million people in the United States. Ischemia represents a serious complicating factor in wound healing. In this paper we analyze a recently developed mathematical model of ischemic dermal wounds. The model consists of a coupled system of partial differential equations in the partially healed region, with the wound boundary as a free boundary. The extracellular matrix (ECM) is assumed to be viscoelastic, and the free boundary moves with the velocity of the ECM at the boundary of the open wound. The model equations involve the concentrations of oxygen, cytokines, and the densities of several types of cells. The ischemic level is represented by a parameter which appears in the boundary conditions, 0 <= gamma < 1; gamma near 1 corresponds to extreme ischemia and gamma = 0 corresponds to normal non-ischemic conditions. We establish global existence and uniqueness of the free boundary problem and study the dependence of the free boundary on gamma.

Affiliated with

Also associated with

No associations

Rating

Analysis of a Mathematical Model of Ischemic Cutaneous wounds does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Analysis of a Mathematical Model of Ischemic Cutaneous wounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analysis of a Mathematical Model of Ischemic Cutaneous wounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-141632