An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21

Details An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21 An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21

2004-11-03

arxiv.org/abs/q-bio/0411015v1

Computational Biology and Chemistry, 28(5-6): 393-399 (2004)

Biology

Quantitative Biology

Genomics

15 pages (figures included), 5 figures

Scientific paper

10.1016/j.compbiolchem.2004.09.0

An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys. The GC-poor valleys comprise regions with low density of CpG islands and, alternating between the two DNA strands, low gene density regions. Consequently, the long-range oscillation of GC% result in spacing patterns of both CpG island density, and to a lesser extent, gene densities.

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