An Information Theoretical Analysis of Kinase Activated Phosphorylation Dephosphorylation Cycle

Biology – Quantitative Biology – Subcellular Processes

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

17 pages, 7 figures

Scientific paper

Signal transduction, the information processing mechanism in biological cells, is carried out by a network of biochemical reactions. The dynamics of driven biochemical reactions can be studied in terms of nonequilibrium statistical physics. Such systems may also be studied in terms of Shannon's information theory. We combine these two perspectives in this study of the basic units (modules) of cellular signaling: the phosphorylation dephosphorylation cycle (PdPC) and the guanosine triphosphatase (GTPase). We show that the channel capacity is zero if and only if the free energy expenditure of biochemical system is zero. In fact, a positive correlation between the channel capacity and free energy expenditure is observed. In terms of the information theory, a linear signaling cascade consisting of multiple steps of PdPC can function as a distributed "multistage code". With increasing number of steps in the cascade, the system trades channel capacity with the code complexity. Our analysis shows that while a static code can be molecular structural based; a biochemical communication channel has to have energy expenditure.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

An Information Theoretical Analysis of Kinase Activated Phosphorylation Dephosphorylation Cycle does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with An Information Theoretical Analysis of Kinase Activated Phosphorylation Dephosphorylation Cycle, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and An Information Theoretical Analysis of Kinase Activated Phosphorylation Dephosphorylation Cycle will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-54735

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.