An ensemble approach to improved prediction from multitype data

Details An ensemble approach to improved prediction from multitype data An ensemble approach to improved prediction from multitype data

2008-05-21

arxiv.org/abs/0805.3286v1

IMS Collections 2008, Vol. 3, 302-317

Statistics

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Published in at http://dx.doi.org/10.1214/074921708000000219 the IMS Collections (http://www.imstat.org/publications/imscollec

Scientific paper

10.1214/074921708000000219

We have developed a strategy for the analysis of newly available binary data to improve outcome predictions based on existing data (binary or non-binary). Our strategy involves two modeling approaches for the newly available data, one combining binary covariate selection via LASSO with logistic regression and one based on logic trees. The results of these models are then compared to the results of a model based on existing data with the objective of combining model results to achieve the most accurate predictions. The combination of model predictions is aided by the use of support vector machines to identify subspaces of the covariate space in which specific models lead to successful predictions. We demonstrate our approach in the analysis of single nucleotide polymorphism (SNP) data and traditional clinical risk factors for the prediction of coronary heart disease.

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