An accurate model for genetic hitch-hiking

Details An accurate model for genetic hitch-hiking An accurate model for genetic hitch-hiking

2007-05-16

arxiv.org/abs/0705.2286v1

Genetics 178, 439 (2008)

Biology

Quantitative Biology

Populations and Evolution

12 pages, 10 figures

Scientific paper

We suggest a simple deterministic approximation for the growth of the favoured-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitch-hiking. Only when Ns < 10 (N is the population size and s denotes the selection coefficient), are discrepancies between our approximation and direct numerical simulations of a Moran model noticeable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

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