Aminoacyl-Nucleotide Reactions - Studies Related to the Origin of the Genetic Code and Protein Synthesis

Details Aminoacyl-Nucleotide Reactions - Studies Related to the Origin of the Genetic Code and Protein Synthesis Aminoacyl-Nucleotide Reactions - Studies Related to the Origin of the Genetic Code and Protein Synthesis

Dec 1984

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1984orli...14..597m&link_type=abstract

Origins of Life, Volume 14, Issue 1-4, pp. 597-604

Mathematics

Logic

Scientific paper

In the present paper, we report on the effect of pH and carbonate on the hydrolysis rate constants of N-blocked and free aminoacyl adenylate anhydrides. Whereas the hydrolysis of free aminoacyly adenylates seems principally catalyzed by OH-, the hydrolysis of the N-blocked species is also catalyzed by H+, giving this compound a U-shaped hydrolysis vs. pH curve. Furthermore, at pH's<8, carbonate has an extreme catalytic effect on the hydrolysis of free aminoacyl-AMP anhydride, but essentially no effect on the hydrolysis of N-blocked aminoacyl-AMP anhydride. Furthermore, the N-blocked aminoacyl-AMP anhydride is a very efficient generator of peptides using free glycine as acceptor. The possible significance of the observations to prebiological peptide synthesis is discussed.

Affiliated with

Also associated with

No associations

Rating

Aminoacyl-Nucleotide Reactions - Studies Related to the Origin of the Genetic Code and Protein Synthesis does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Aminoacyl-Nucleotide Reactions - Studies Related to the Origin of the Genetic Code and Protein Synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoacyl-Nucleotide Reactions - Studies Related to the Origin of the Genetic Code and Protein Synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-739068