Alternative Splicing and Genomic Stability

Details Alternative Splicing and Genomic Stability Alternative Splicing and Genomic Stability

2004-03-27

arxiv.org/abs/q-bio/0403039v2

Physical Biology, volume 1, issue 2, pages C1 - C4, 2004

Biology

Quantitative Biology

Genomics

6 pages

Scientific paper

10.1088/1478-3967/1/2/C01

Alternative splicing allows an organism to make different proteins in different cells at different times, all from the same gene. In a cell that uses alternative splicing, the total length of all the exons is much shorter than in a cell that encodes the same set of proteins without alternative splicing. This economical use of exons makes genes more stable during reproduction and development because a genome with a shorter exon length is more resistant to harmful mutations. Genomic stability may be the reason why higher vertebrates splice alternatively. For a broad class of alternatively spliced genes, a formula is given for the increase in their stability.

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