Aging and Immortality in a Cell Proliferation Model

Details Aging and Immortality in a Cell Proliferation Model Aging and Immortality in a Cell Proliferation Model

2006-09-26

arxiv.org/abs/q-bio/0609040v2

Journal of Theoretical Biology 248, 411-417 (2007)

Biology

Quantitative Biology

Cell Behavior

6 pages, 1 figure, 2-column revtex4 format; version 2: final published form; contains various improvements in response to refe

Scientific paper

10.1016/j.jtbi.2007.06.009

We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres become shorter than a critical length. In addition to this systematic shortening, exchange of telomere DNA between the two daughter cells can occur at each cell division. We map this telomere dynamics onto a biased branching diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. As the relative effects of telomere shortening and cell division are varied, there is a phase transition between finite lifetime and infinite proliferation of the cell population. Using simple first-passage ideas, we quantify the nature of this transition.

Affiliated with

Also associated with

No associations

Rating

Aging and Immortality in a Cell Proliferation Model does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Aging and Immortality in a Cell Proliferation Model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aging and Immortality in a Cell Proliferation Model will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-261317