Adaptive hormetic response of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co γ-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation

Details Adaptive hormetic response of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co γ-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation Adaptive hormetic response of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co γ-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation

Jan 2006

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2006adspr..38.1148z&link_type=abstract

Advances in Space Research, Volume 38, Issue 6, p. 1148-1151.

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The brain of the Kun-Ming strain mice were irradiated with 0.05 Gy of 12C6+ ion or 60Co γ-ray as the pre-exposure dose, and were then irradiated with 2 Gy of 12C6+ ion or 60Co γ-ray as challenging irradiation dose at 4 h after per-exposure. Body weight and serum growth hormone (GH) concentration were measured at 35th day after irradiation. The results showed that irradiation of mouse brain with 2 Gy of 12C6+ ion or 60Co γ-ray significantly diminished mouse body weight and level of serum GH. The relative biological effectiveness values of a 2 Gy dose of 12C6+ ion calculated with respect to 60Co γ-ray were 1.47 and 1.34 for body weight and serum GH concentration, respectively. Pre-exposure with a low-dose (0.05 Gy) of 12C6+ ion or 60Co γ-ray significantly alleviated reductions of mouse body weight and level of serum GH induced by a subsequent high-dose (2 Gy) irradiation. The data suggested that low-dose ionizing irradiation can induce adaptive hormetic responses to the harmful effects of pituitary by subsequent high-dose exposure.

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