Biology – Quantitative Biology – Populations and Evolution
Scientific paper
2005-08-05
Structural Approaches to Sequence Evolution, Eds.: U. Bastolla, M. Porto, H.E. Roman, M. Vendruscolo, Springer Berlin, 2007, p
Biology
Quantitative Biology
Populations and Evolution
To appear in "Structural approaches to sequence evolution: Molecules, networks and populations", ed. by U. Bastolla, M. Porto,
Scientific paper
This is an introductory review of deterministic mutation-selection models for asexual populations (i.e., quasispecies theory) and related topics. First, the basic concepts of fitness, mutations, and sequence space are introduced. Different types of mutation-selection dynamics are defined and their relation to problems of statistical physics are outlined. Then the stationary population distribution in simple, single peak fitness landscapes is discussed at length, with particular emphasis on the error threshold phenomenon. Extensions of the theory covering e.g. epistatic interactions, diploid organisms, semiconservative replication and time-dependent fitness peaks are briefly described. A further section is devoted to randomly rugged fitness landscapes, which may display fitness correlations of various degree as well as extended neutral networks. The final two sections address evolutionary dynamics in both rugged and smooth fitness landscapes, and provide a brief overview of pertinent experiments.
Jain Kavita
Krug Joachim
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