A unifying framework for seed sensitivity and its application to subset seeds (Extended abstract)

Details A unifying framework for seed sensitivity and its application to subset seeds (Extended abstract) A unifying framework for seed sensitivity and its application to subset seeds (Extended abstract)

2006-03-27

arxiv.org/abs/cs/0603105v1

Algorithms in Bioinformatics, LNBI 3692 : 251-263, 2005

Computer Science

Other Computer Science

Scientific paper

10.1007/11557067_21

We propose a general approach to compute the seed sensitivity, that can be applied to different definitions of seeds. It treats separately three components of the seed sensitivity problem - a set of target alignments, an associated probability distribution, and a seed model - that are specified by distinct finite automata. The approach is then applied to a new concept of subset seeds for which we propose an efficient automaton construction. Experimental results confirm that sensitive subset seeds can be efficiently designed using our approach, and can then be used in similarity search producing better results than ordinary spaced seeds.

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