A two-phase approach for detecting recombination in nucleotide sequences

Details A two-phase approach for detecting recombination in nucleotide sequences A two-phase approach for detecting recombination in nucleotide sequences

2007-09-12

arxiv.org/abs/0709.1874v1

Biology

Quantitative Biology

Populations and Evolution

5 pages, 3 figures. Chan CX, Beiko RG and Ragan MA (2007). A two-phase approach for detecting recombination in nucleotide sequ

Scientific paper

Genetic recombination can produce heterogeneous phylogenetic histories within a set of homologous genes. Delineating recombination events is important in the study of molecular evolution, as inference of such events provides a clearer picture of the phylogenetic relationships among different gene sequences or genomes. Nevertheless, detecting recombination events can be a daunting task, as the performance of different recombinationdetecting approaches can vary, depending on evolutionary events that take place after recombination. We recently evaluated the effects of postrecombination events on the prediction accuracy of recombination-detecting approaches using simulated nucleotide sequence data. The main conclusion, supported by other studies, is that one should not depend on a single method when searching for recombination events. In this paper, we introduce a two-phase strategy, applying three statistical measures to detect the occurrence of recombination events, and a Bayesian phylogenetic approach in delineating breakpoints of such events in nucleotide sequences. We evaluate the performance of these approaches using simulated data, and demonstrate the applicability of this strategy to empirical data. The two-phase strategy proves to be time-efficient when applied to large datasets, and yields high-confidence results.

Affiliated with

Also associated with

No associations

Rating

A two-phase approach for detecting recombination in nucleotide sequences does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with A two-phase approach for detecting recombination in nucleotide sequences, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A two-phase approach for detecting recombination in nucleotide sequences will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-22663