A thermodynamic switch for chromosome colocalization

Details A thermodynamic switch for chromosome colocalization A thermodynamic switch for chromosome colocalization

2008-09-27

arxiv.org/abs/0809.4788v1

Genetics 179, 717 (2008)

Biology

Quantitative Biology

Subcellular Processes

Scientific paper

A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on a thermodynamic ground, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.

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