Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2005-11-29
Phys. Biol. 3 (2006) 1-12
Biology
Quantitative Biology
Subcellular Processes
19 pages, 12 figures (25 figure files); published at http://www.iop.org/EJ/journal/physbio
Scientific paper
10.1088/1478-3975/3/1/001
The Min system in Escherichia coli directs division to the centre of the cell through pole-to-pole oscillations of the MinCDE proteins. We present a one dimensional stochastic model of these oscillations which incorporates membrane polymerisation of MinD into linear chains. This model reproduces much of the observed phenomenology of the Min system, including pole-to-pole oscillations of the Min proteins. We then apply this model to investigate the Min system during cell division. Oscillations continue initially unaffected by the closing septum, before cutting off rapidly. The fractions of Min proteins in the daughter cells vary widely, from 50%-50% up to 85%-15% of the total from the parent cell, suggesting that there may be another mechanism for regulating these levels in vivo.
Howard Martin
Tostevin Filipe
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