Mathematics – Analysis of PDEs
Scientific paper
2008-12-03
Mathematics
Analysis of PDEs
Scientific paper
Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested that the collagen network surrounding the muscular fibers could account for these mechanical behaviors. To test this hypothesis we develop a model for large deformation response of active, incompressible, nonlinear elastic and transversely isotropic living soft tissue (such as cardiac or arteries tissues) in which we include a coupling effect between the connective tissue and the muscular fibers. Then, a three-dimensional finite element formulation including this internal pseudo-active kinematic constraint is derived. Analytical and finite element solutions are in a very good agreement. The numerical results show this wall thickening effect with an order of magnitude compatible with the experimental observations.
Bourdarias Christian
Gerbi Stéphane
Ohayon Jacques
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