A Physical Theory of the Competition that Allows HIV to Escape from the Immune System

Details A Physical Theory of the Competition that Allows HIV to Escape from the Immune System A Physical Theory of the Competition that Allows HIV to Escape from the Immune System

2006-10-08

arxiv.org/abs/q-bio/0610018v2

Biology

Quantitative Biology

Populations and Evolution

5 pages, 2 figures, to appear in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.97.188106

Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The analytical model reproduces the three stages of HIV-1 infection. We propose a vaccine regimen that may be able to reduce competition between T cells, potentially eliminating the third stage of HIV-1.

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