A Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes

Details A Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes A Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes

2005-12-12

arxiv.org/abs/q-bio/0512027v2

FEBS Letters 580 (2006) 368-372

Biology

Quantitative Biology

Subcellular Processes

Scientific paper

10.1016/j.febslet.2005.12.053

During the eukaryotic cell cycle, chromatin undergoes several conformational changes, which are believed to play key roles in gene expression regulation during interphase, and in genome replication and division during mitosis. In this paper, we propose a scenario for chromatin structural reorganization during mitosis, which bridges all the different scales involved in chromatin architecture, from nucleosomes to chromatin loops. We build a model for chromatin, based on available data, taking into account both physical and topological constraints DNA has to deal with. Our results suggest that the mitotic chromosome condensation/decondensation process is induced by a structural change at the level of the nucleosome itself.

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