A New Family of Covariate-Adjusted Response Adaptive Designs and their Asymptotic Properties

Details A New Family of Covariate-Adjusted Response Adaptive Designs and their Asymptotic Properties A New Family of Covariate-Adjusted Response Adaptive Designs and their Asymptotic Properties

2008-12-19

arxiv.org/abs/0812.3691v1

Appl. Math. J. Chinese Univ. 2009, 24(1): 1-13

Statistics

Methodology

Scientific paper

10.1007/s11766-009-0001-6

It is often important to incorporating covariate information in the design of clinical trials. In literature, there are many designs of using stratification and covariate-adaptive randomization to balance on certain known covariate. Recently Zhang, Hu, Cheung and Chan (2007) have proposed a family of covariate-adjusted response-adaptive (CARA) designs and studied their asymptotic properties. However, these CARA designs often have high variabilities. In this paper, we propose a new family of covariate-adjusted response-adaptive (CARA) designs. We show that the new designs have smaller variabilities and therefore more efficient.

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