A network model to investigate structural and electrical properties of proteins

Biology – Quantitative Biology – Quantitative Methods

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

25 pages, 12 figures

Scientific paper

One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest. In fact, it has been shown that proteins like bacteriorhodopsin and azurin, manifest electrical properties which are promising for the development of active components in the field of molecular electronics. Here we focus on two relevant kinds of proteins: The bovine rhodopsin, prototype of GPCR protein, and the enzyme acetylcholinesterase (AChE), whose inhibition is one of the most qualified treatments of Alzheimer disease. Both these proteins exert their functioning starting with a conformational change of their native structure. Our guess is that such a change should be accompanied with a detectable variation of their electrical properties. To investigate this conjecture, we present an impedance network model of proteins, able to estimate the different electrical response associated with the different configurations. The model resolution of the electrical response is found able to monitor the structure and the conformational change of the given protein. In this respect, rhodopsin exhibits a better differential response than AChE. This result gives room to different interpretations of the degree of conformational change and in particular supports a recent hypothesis on the existence of a mixed state already in the native configuration of the protein.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

A network model to investigate structural and electrical properties of proteins does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with A network model to investigate structural and electrical properties of proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A network model to investigate structural and electrical properties of proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-651280

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.