Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2008-08-17
Biology
Quantitative Biology
Neurons and Cognition
11 pages, 6 figures, 4 page bibliography
Scientific paper
We discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of this model depends on an entire set of physiological parameters, representing synaptic strengths, vulnerability to stress-induced cortisol, dopamine regulation and rates of autoantibody production. Malfunction of different such parameters produces similar outward dysregulation of the system, which may readily lead to diagnosis difficulties in a clinician's office. We further place this paradigm within the contexts of pathophysiology and of antipsychotic pharmacology. We finally propose brain profiling as the future quantitative diagnostic toolbox that agrees with a multiple etiologies hypothesis of schizophrenia.
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