A model of dissociated cortical tissue

Biology – Quantitative Biology – Neurons and Cognition

Scientific paper

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4 pages, 8 PDF figure files, uses graphicx, mathptmx, helvet, courier, amsmath, and 1 custom style file

Scientific paper

A powerful experimental approach for investigating computation in networks of biological neurons is the use of cultured dissociated cortical cells grown into networks on a multi-electrode array. Such preparations allow investigation of network development, activity, plasticity, responses to stimuli, and the effects of pharmacological agents. They also exhibit whole-culture pathological bursting; understanding the mechanisms that underlie this could allow creation of more useful cell cultures and possibly have medical applications.

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