A Model for the Development of Genetic Translation

Details A Model for the Development of Genetic Translation A Model for the Development of Genetic Translation

Dec 1982

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1982orli...12..405k&link_type=abstract

Origins of Life, Volume 12, Issue 4, pp.405-425

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Scientific paper

Several models have been advanced, both in this journal and others, for the development of the genetic code and translation apparatus. Eigen in particular has put forward a detailed model based on the hypercycle. This paper uses some of these previous ideas to develop a new model of the code and translation in which the pairs AU and GC play complementary roles, and in whichtRNAs develop from a molecule withtwo loops which stacks in repetitive patterns without the need for a messenger RNA. Thus a bridge is provided between random, (or autocatalytic) polymerization, and coded translation. In addition, alternative postulates to several of Eigen's ideas are tested by computer simulation.

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