A model for signal transduction during quorum sensing in \emph{Vibrio harveyi}

Details A model for signal transduction during quorum sensing in \emph{Vibrio harveyi} A model for signal transduction during quorum sensing in \emph{Vibrio harveyi}

2009-10-12

arxiv.org/abs/0910.2084v1

Phys. Biol. 6 (2009) 046008

Biology

Quantitative Biology

Cell Behavior

18 pages, 5 figures, IOP style files included

Scientific paper

10.1088/1478-3975/6/4/046008

We present a framework for analyzing luminescence regulation during quorum sensing in the bioluminescent bacterium \emph{Vibrio harveyi}. Using a simplified model for signal transduction in the quorum sensing pathway, we identify key dimensionless parameters that control the system's response. These parameters are estimated using experimental data on luminescence phenotypes for different mutant strains. The corresponding model predictions are consistent with results from other experiments which did not serve as inputs for determining model parameters. Furthermore, the proposed framework leads to novel testable predictions for luminescence phenotypes and for responses of the network to different perturbations.

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