Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2007-10-30
Comput. Math. Methods Med. 10:71-83, 2009
Biology
Quantitative Biology
Quantitative Methods
15 pages, 4 figures; to appear in Computational and Mathematical Methods in Medicine
Scientific paper
Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion. Coupling mathematical modeling and experiments, we investigate the growth and motility of oncogene--expressing human mammary epithelial cells under exposure to TGF--$\beta$. We use a version of the well--known Fisher--Kolmogorov equation, and prescribe a procedure for its parametrization. We quantify the simultaneous effects of TGF--$\beta$ to increase the tendency of individual cells and cell clusters to move randomly and to decrease overall population growth. We demonstrate that in experiments with TGF--$\beta$ treated cells \textit{in vitro}, TGF--$\beta$ increases cell motility by a factor of 2 and decreases cell proliferation by a factor of 1/2 in comparison with untreated cells.
Arteaga Carlos L.
Bryce Nicole
Estrada Lourdes
Hinow Peter
Wang Shizhen Emily
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