A Complete Enumeration and Classification of Two-Locus Disease Models

Details A Complete Enumeration and Classification of Two-Locus Disease Models A Complete Enumeration and Classification of Two-Locus Disease Models

1999-08-05

arxiv.org/abs/adap-org/9908001v1

Human Heredity, 50(6):334-349 (2000)

Nonlinear Sciences

Adaptation and Self-Organizing Systems

LaTeX, to be published in Human Heredity

Scientific paper

10.1159/000022939

There are 512 two-locus, two-allele, two-phenotype, fully-penetrant disease models. Using the permutation between two alleles, between two loci, and between being affected and unaffected, one model can be considered to be equivalent to another model under the corresponding permutation. These permutations greatly reduce the number of two-locus models in the analysis of complex diseases. This paper determines the number of non-redundant two-locus models (which can be 102, 100, 96, 51, 50, or 48, depending on which permutations are used, and depending on whether zero-locus and single-locus models are excluded). Whenever possible, these non-redundant two-locus models are classified by their property. Besides the familiar features of multiplicative models (logical AND), heterogeneity models (logical OR), and threshold models, new classifications are added or expanded: modifying-effect models, logical XOR models, interference and negative interference models (neither dominant nor recessive), conditionally dominant/recessive models, missing lethal genotype models, and highly symmetric models. The following aspects of two-locus models are studied: the marginal penetrance tables at both loci, the expected joint identity-by-descent probabilities, and the correlation between marginal identity-by-descent probabilities at the two loci. These studies are useful for linkage analyses using single-locus models while the underlying disease model is two-locus, and for correlation analyses using the linkage signals at different locations obtained by a single-locus model.

Affiliated with

Also associated with

No associations

Rating

A Complete Enumeration and Classification of Two-Locus Disease Models does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with A Complete Enumeration and Classification of Two-Locus Disease Models, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A Complete Enumeration and Classification of Two-Locus Disease Models will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-74597