[3H]GABA Binding in Brains from Huntington's Chorea Patients: Altered Regulation by Phospholipids?

Details [3H]GABA Binding in Brains from Huntington's Chorea Patients: Altered Regulation by Phospholipids? [3H]GABA Binding in Brains from Huntington's Chorea Patients: Altered Regulation by Phospholipids?

Sep 1979

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1979sci...205.1147l&link_type=abstract

Science, Volume 205, Issue 4411, pp. 1147-1149

Computer Science

Scientific paper

Binding sites for tritium-labeled γ -aminobutyric acid (GABA) in cerebellar cortex of Huntington's chorea patients have an increased affinity but unaltered maximum capacity as compared to binding sites in tissue from control patients. A similar binding pattern is produced in control membranes by treatment with Triton X-100, phospholipase C, or glycerophosphoethanolamine. Thus, it is likely that phospholipids or their metabolites regulate the accessibility of the GABA binding site and that this regulation is abnormal in Huntington's chorea.

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