Experiments on the Amplification of Optical Activity

Details Experiments on the Amplification of Optical Activity Experiments on the Amplification of Optical Activity

Sep 1980

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1980orli...10..255b&link_type=abstract

Origins of Life, Volume 10, Issue 3, pp.255-263

Computer Science

4

Scientific paper

By way of investigating possible mechanisms for the abiotic amplification of small enantiomeric excesses (e.e.'s) in almost racemic mixtures of amino acid enantiomers, we have undertaken a quantitative study of the base-initiated partial polymerization of leucine and valineN-carboxy-anhydride (NCA) enantiomer mixtures containing known excesses of both theR- andS-forms. Polymerization to the extent ofca. 50% of leucine NCA having an 8 70% e.e. of either theR- orS-enantiomer led to an e.e. enhancement in the polymer, which contained a 12 84% e.e. of that enantiomer which predominated in the original monomer NCA. A corresponding decrease in the e.e. of the initially predominant enantiomer was noted in the unpolymerized residue from each reaction. Polymerization to the extent of 25 50% of mixtures of valine NCA enantiomers containing a 12 13% e.e. of eitherR- orS-isomer led to polymers showing a 7 8%decrease in the e.e. of the initially predominant enantiomer, and to an increase of its e.e. in the unpolymerized residue. These divergent results, the latter of which is quite novel, are compared with earlier qualitative results in the literature and are discussed briefly from the viewpoint of both mechanism and the amplification of optical activity.

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