Specific effect of magnesium ion on 2', 3'-cyclic amp synthesis from adenosine and trimeta phosphate in aqueous solution

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Scientific paper

Phosphorylation of adenosine by trimetaphosphate was investigated using various catalysts in aqueous solution under mild conditions at pH ˜ 7.0 and at 41 °C. The product was primarily 2',3'-cyclic AMP together with smaller amounts of ATP. Magnesium ion was found to have a remarkable catalytic effect of approximately one hundred times greater than the other chemicals tested. The mechanism for the specific effect of magnesium ion is discussed.

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