The Prebiotic Chemistry of Nucleotides

Details The Prebiotic Chemistry of Nucleotides The Prebiotic Chemistry of Nucleotides

Dec 1984

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1984orli...14...99f&link_type=abstract

Origins of Life, Volume 14, Issue 1-4, pp. 99-106

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Scientific paper

Diiminosuccinonitrile (DISN), formed by the oxidation of diaminomaleonitrile (DAMN), has been investigated as a potential prebiotic phosphorylating agent. DISN effects the cyclization of 3'-adenosine monophosphate to adenosine 2', 3'-cyclic phosphate in up to 39% yield. The mechanism of this reaction was investigated. The DISN-mediated phosphorylation of uridine to uridine monophosphate does not proceed efficiently in aqueous solution. The reaction of DISN with uridine-5'-phosphate and uridine results in the formation of 2,2'-anhydronucleotides and 2,2'-anhydronucleosides respectively, and other reaction products resulting from an initial reaction at the 2'- and 3'-hydroxyl groups. The clay mineral catalysis of the cyclization of adenosine-3'-phosphate was investigated using homoionic montmorillonites.

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