Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2008-06-12
Biology
Quantitative Biology
Quantitative Methods
14 pages, 1 figure
Scientific paper
10.1016/j.physa.2008.08.024
We provide a complete thermodynamic solution of a 1D hopping model in the presence of a random potential by obtaining the density of states. Since the partition function is related to the density of states by a Laplace transform, the density of states determines completely the thermodynamic behavior of the system. We have also shown that the transfer matrix technique, or the so-called dynamic programming, used to obtain the density of states in the 1D hopping model may be generalized to tackle a long-standing problem in statistical significance assessment for one of the most important proteomic tasks - peptide sequencing using tandem mass spectrometry data.
Alves Gelio
Yu Yi-Kuo
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