Biology – Quantitative Biology – Genomics
Scientific paper
2012-03-29
Biology
Quantitative Biology
Genomics
17 pages including 1 Figure and 6 Tables
Scientific paper
It is well known that the general transcription factors (GTF) specifically recognize correct TATA boxes, distinguishing them from many others. Employing the principles of determinacy analysis (mathematical theory of rules) we analyzed a fragment of human chromosome 1 DNA sequence and identified specific genetic markers (IG-markers = Irreducible Genetic markers) in the nearest proximity to TATAAA motifs. The IG-markers enable determining the exact location of any TATAAA motif within the investigated DNA fragment. Based on our data we hypothesize that the GTF recognize the {\guillemotleft}true{\guillemotright} transcriptional start TATA box by means of IG-markers. The math method described here is universal and can be used to find IG-markers that will provide, like a global navigation satellite system, for the specific location of any distinct sequence motif within larger DNA sequence content.
Chesnokov Lina G.
Chesnokov Sergey V.
Wixler Viktor
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