Mathematics – Statistics Theory
Scientific paper
2007-10-11
Annals of Statistics 2007, Vol. 35, No. 4, 1351-1377
Mathematics
Statistics Theory
Published in at http://dx.doi.org/10.1214/009053606000001460 the Annals of Statistics (http://www.imstat.org/aos/) by the Inst
Scientific paper
10.1214/009053606000001460
Modern scientific technology has provided a new class of large-scale simultaneous inference problems, with thousands of hypothesis tests to consider at the same time. Microarrays epitomize this type of technology, but similar situations arise in proteomics, spectroscopy, imaging, and social science surveys. This paper uses false discovery rate methods to carry out both size and power calculations on large-scale problems. A simple empirical Bayes approach allows the false discovery rate (fdr) analysis to proceed with a minimum of frequentist or Bayesian modeling assumptions. Closed-form accuracy formulas are derived for estimated false discovery rates, and used to compare different methodologies: local or tail-area fdr's, theoretical, permutation, or empirical null hypothesis estimates. Two microarray data sets as well as simulations are used to evaluate the methodology, the power diagnostics showing why nonnull cases might easily fail to appear on a list of ``significant'' discoveries.
No associations
LandOfFree
Size, power and false discovery rates does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Size, power and false discovery rates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Size, power and false discovery rates will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-541888