Biology – Quantitative Biology – Cell Behavior
Scientific paper
2009-04-29
Biology
Quantitative Biology
Cell Behavior
16 pages, 19 figures
Scientific paper
This paper deals with a model of cellular growth called "Epigenetic Tracking", whose key features are: i) distinction bewteen "normal" and "driver" cells; ii) presence in driver cells of an epigenetic memory, that holds the position of the cell in the driver cell lineage tree and represents the source of differentiation during development. In the first part of the paper the model is proved able to generate arbitrary target shapes of unmatched size and variety by means of evo-devo techniques, thus being validated as a model of embryogenesis and cellular differentiation. In the second part of the paper it is shown how the model can produce artificial counterparts for some key aspects of multicellular biology, such as junk DNA, ageing and carcinogenesis. If individually each of these topics has been the subject of intense investigation and modelling effort, to our knowledge no single model or theory seeking to cover all of them under a unified framework has been put forward as yet: this work contains such a theory, which makes Epigenetic Tracking a potential basis for a project of Artificial Biology.
No associations
LandOfFree
Epigenetic Tracking: Towards a Project for an Artificial Biology does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Epigenetic Tracking: Towards a Project for an Artificial Biology, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epigenetic Tracking: Towards a Project for an Artificial Biology will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-512585