Results and Limitations of the Soliton Theory of DNA Transcription

Details Results and Limitations of the Soliton Theory of DNA Transcription Results and Limitations of the Soliton Theory of DNA Transcription

2003-12-16

arxiv.org/abs/q-bio/0312024v1

Journal of Biological Physics 24 (1999), 81-96

Biology

Quantitative Biology

Other Quantitative Biology

An older review paper (NOT UPDATED), posted here for archival purposes

Scientific paper

It has been suggested by several authors that nonlinear excitations, in particular solitary waves, could play a fundamental functional role in the process of DNA transcription, effecting the opening of the double chain needed for RNA Polymerase to be able to copy the genetic code. Some models have been proposed to model the relevant DNA dynamics in terms of a reduced number of effective degrees of freedom. Here I discuss advantages and disadvantages of such an approach, and discuss in more detail one of the models, i.e. the one proposed by Yakushevich.

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