Laplacian Spectrum and Protein-Protein Interaction Networks

Details Laplacian Spectrum and Protein-Protein Interaction Networks Laplacian Spectrum and Protein-Protein Interaction Networks

2007-05-23

arxiv.org/abs/0705.3373v1

Biology

Quantitative Biology

Quantitative Methods

7 pages, 3 figures

Scientific paper

From the spectral plot of the (normalized) graph Laplacian, the essential qualitative properties of a network can be simultaneously deduced. Given a class of empirical networks, reconstruction schemes for elucidating the evolutionary dynamics leading to those particular data can then be developed. This method is exemplified for protein-protein interaction networks. Traces of their evolutionary history of duplication and divergence processes are identified. In particular, we can identify typical specific features that robustly distinguish protein-protein interaction networks from other classes of networks, in spite of possible statistical fluctuations of the underlying data.

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