Ancestral Graph with Bias in Gene Conversion

Details Ancestral Graph with Bias in Gene Conversion Ancestral Graph with Bias in Gene Conversion

2009-07-07

arxiv.org/abs/0907.1127v2

Biology

Quantitative Biology

Populations and Evolution

29 pages, 2 figures

Scientific paper

Gene conversion is a mechanism by which a double-strand break in a DNA molecule is repaired using a homologous DNA molecule as a template. As a result, one gene is 'copied and pasted' onto the other gene. It was recently reported that the direction of gene conversion appears to be biased towards G and C nucleotides. In this paper a stochastic model of the dynamics of the bias in gene conversion is developed for a finite population of members in a multigene family. The dual process is the biased voter model, which generates an ancestral random graph for a given sample. An importance-sampling algorithm for computing the likelihood of the sample is also given.

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