VE-cadherin and claudin-5: it takes two to tango

Details VE-cadherin and claudin-5: it takes two to tango VE-cadherin and claudin-5: it takes two to tango

2008-11-25

arxiv.org/abs/0811.4025v1

Nat Cell Biol 10, 8 (2008) 883-5

Biology

Quantitative Biology

Cell Behavior

Scientific paper

10.1038/ncb0808-883

Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

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