Mathematics – Logic
Scientific paper
Feb 2004
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004oleb...34..143a&link_type=abstract
Origins of Life and Evolution of the Biosphere, v. 34, Issue 1, p. 143-149 (2004).
Mathematics
Logic
Scientific paper
The concept of DNA as a simple repository of the gene information has changed in that of a polymorphic macromolecule, which plays a relevant part in the management of the complex biochemical transformations in living matter. As a consequence of the slight stereochemical differences between base pairs, the direction of the DNA double helix axis undergoes deterministic writhing. A useful representation of such sequence-dependent structural distortions is the curvature diagram. Here, it is reported as an evolution simulation obtained by extensive point mutations along a biologically important DNA tract. The curvature changes, consequence of the point mutations, were compared to the related experimental gel electrophoresis mobility. The curvature of most mutants decreases and the mobility increases accordingly, suggesting the curvature of that tract is genetically selected. Moreover, DNA images by scanning force microscopy, show evidence of a sequence-dependent adhesion of curved DNA tracts to inorganic crystal surfaces. In particular, mica shows a large affinity towards the TT-rich dinucleotide sequences. This suggests a possible mechanism of selection of curved DNA regions, characterized by AA ˙ TT dinucleotides in phase with double-helical periodicity, in the very early evolution steps.
Anselmi Claudio
de Santis Pasquale
Paparcone Raffaella
Savino Maria
Scipioni Anita
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