Chiral Amplification of Oligopeptides via Polymerization in Two-dimensional Crystallites on Water

Details Chiral Amplification of Oligopeptides via Polymerization in Two-dimensional Crystallites on Water Chiral Amplification of Oligopeptides via Polymerization in Two-dimensional Crystallites on Water

Feb 2004

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004oleb...34...79w&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 34, Issue 1, p. 79-92 (2004).

Computer Science

Scientific paper

A possible role that might have been played by ordered clusters at the air/water interface for the generation of homochiral oligopeptides under prebiotic conditions has been probed by a catalyzed polymerization of amphiphilic activated α-amino acids that assembled as two-dimensional (2-D) crystallites at this interface. Three type of processes are described: (i) polymerization of racemates of activated α-amino acids that undergo spontaneous resolution into enantiomorphous 2-D crystallites to yield racemic mixtures of oligopeptides enriched with the oligomers of homochiral sequence, (ii) enhanced formation of racemic mixtures of homochiral oligopeptides via lattice-controlled polymerization within 2-D racemic compounds and (iii) generation of homochiral oligopeptides of a single handedness from chiral non-racemic mixtures of monomers that self-assemble into two different phases, racemic crystallites composed from both enantiomers and enantiomorphous crystallites of the enantiomer in excess. The structures of the 2-D crystallites have been determined by grazing incidence X-ray diffraction and the diastereoisomeric composition of the oligopeptides by matrix-assisted laser-desorption time-of-flight mass spectrometry with enantio-labeling.

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