Heterogeneous diversity of spacers within CRISPR

Details Heterogeneous diversity of spacers within CRISPR Heterogeneous diversity of spacers within CRISPR

2010-08-16

arxiv.org/abs/1008.2714v1

Biology

Quantitative Biology

Populations and Evolution

5 pages, 5 figures, to appear in Phys. Rev. Lett

Scientific paper

Clustered regularly interspaced short palindromic repeats (CRISPR) in bacterial and archaeal DNA have recently been shown to be a new type of anti-viral immune system in these organisms. We here study the diversity of spacers in CRISPR under selective pressure. We propose a population dynamics model that explains the biological observation that the leader-proximal end of CRISPR is more diversified and the leader-distal end of CRISPR is more conserved. This result is shown to be in agreement with recent experiments. Our results show thatthe CRISPR spacer structure is influenced by and provides a record of the viral challenges that bacteria face.

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