Increased spontaneous transmitter release from presynaptic nerve terminal by methylmercuric chloride

Mathematics – Logic

Scientific paper

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Scientific paper

IN recent years, several incidences of methylmercury pollution have been documented1,2, one of the most striking alterations induced by the compound being extensive damage to the nervous system. Experimental mercury poisoning has been produced in animals3,5, detailed morphological studies of which have shown that acute changes occur initially in the peripheral nerve fibres and thereafter in the central nerve cells3,4. Little is known, however, about functional changes in the nervous system, particularly in the initial stages of poisoning. This report describes one possible target site-the synaptic transmission in the sympathetic ganglia-for methylmercury poisoning. The study is also of interest, as a number of heavy metallic ions such as La3+, Co2+ and Mn2+ have recently been reported to have profound effects on neuromuscular transmission6-9.

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